Wang (Jane) Lab

The Wang laboratory’s research interests are focused on understanding the signaling mechanisms and functions, and therapeutic targeting of diacylglycerol (DAG)-regulated protein kinases, particularly the protein kinase D (PKD) and protein kinase C (PKC) family kinases. These kinases have been strongly implicated in various stages of cancer development. Currently, the group is studying how PKD contributes to cancer cell growth, survival, migration and invasion, validate PKD as a therapeutic target for cancer, and develop novel small molecules that target PKD for therapeutic applications. The laboratory exploits a range of interdisciplinary approaches including methods of biochemistry, molecular biology, fluorescence imaging, structure biology, histology, animal models, and employs contemporary drug design and discovery approaches.

Qiming Jane Wang, PhD
Associate Professor

Qiming Jane Wang, PhD

Ye J, Das S, Roy A, Wei W, Huang H, Lorenz-Guertin JM, Xu Q, Jacob TC, Wang B, Sun D and  Wang Q.J. (2018) Ischemic injury-induced CaMKIIδ and CaMKIIγ confer neuroprotection through the NF-κB signaling pathway. Mol Neurobiol, in press.
Roy A, Veroli MV, Prasad S and Wang QJ. (2018) Protein kinase D2 modulates cell cycle by stabilizing Aurora A kinase at centrosomes. Mol Cancer Res 16:1785-1797, 2018.
Roy A, J Ye, F Deng and QJ Wang.  Protein kinase D signaling in cancer:  A friend or foe?  Biochimica et Biophysica Acta:  Reviews on Cancer 1868:283-294, 2017.
Li S, W Xu, Z Xing, J Qian, L Chen, R Gu, W Guo, X Lai, W Zhao, S Li, Y Wang, QJ Wang and F Deng.  A conditional knockout mouse model reveals a critical role of PKD1 in osteoblast differentiation and bone development.  Scientific Reports 7:40505, 2017.
Zhang L, Z Zhao, S Xu, M Tandon, CR LaValle, F Deng and QJ Wang.  Androgen suppresses protein kinase D1 expresion through fibroblast growth factor receptor substrate 2 in prostate cancer cells.  Oncotarget 8:12800-12811, 2017.
Xu Q, F Deng, Y Qin, Z Zhao, Z Wu, Z Xing, A Ji and QJ Wang.  Long non-coding RNA regulation of epithelial-mesenchymal transition in cancer metastasis.  Cell Death and Disease 7:e2254, 2016.
Xu Q, F Deng, Z Xing, Z Wu, B Cen, S Xu, Z Zhao, R Nepomuceno, MIH Bhuiyan, D Sun, QJ Wang and A Ji.  Long non-coding RNA C2dat1 regulates CaMKIIδ expression to promote neuronal survival through the NF-κB signaling pathway following cerebral ischemia.  Cell Death and Disease 7:e2173, 2016.
Tandon M, Salamoun JM, Carder E, Farber E, Xu S, Deng F, Tang H, Wipf P and Wang QJ. SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest. PLoS One 10:e0119346, 2015.
Liou G-Y, Döppler H, Braun U, Panayiotou R, Buzhardt MS, Radisky D, Crawford H, Fields A, Murray NR, Wang QJ, Leitges M and Storz P. Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia. Nat Commun 6:6200, 2015.
Xu X, Gera N, Li H, Yun M, Zhang L, Wang Y, Wang QJ and Jin T. GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis. Mol Biol Cell 26:874-886, 2015.
Wang P, Han L, Shen H, Wang P, Lv C, Zhao G, Niu J, Xue L, Wang QJ, Tong T and Chen J. Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation. Proc Natl Acad Sci USA 111:7683-7638, 2014.