Research Areas

Primary faculty research interests in the department span several concentrations:


Benign Urologic Disorders


Faculty

jmbeckel@pitt.edu
412-383-5004
wcd2@pitt.edu
412-648-9357
dod1@pitt.edu
412-624-4259

Cancer Genomics


Faculty

leeav@upmc.edu
412-641-7557
arbelyy@upmc.edu
412-623-3228

Cancer Pharmacology

Research efforts in cancer pharmacology include studies of the basic mechanisms of signal transduction associated with cell proliferation and apoptosis, the mechanisms of action of anti-neoplastic agents, the design and discovery of new drugs, basic mechanisms of DNA repair and DNA damage tolerance and the development of novel strategies for gene therapy

Emphasis is placed on the description and characterization of basic signaling mechanisms that constitute the targets of molecules used for cancer therapy and DNA damage and repair mechanisms that contribute to anti-neoplastic drug resistance. The regulation of tyrosine kinases, processing of proto-oncogenes, regulation of small GTPases and their effectors, cell-cycle-specific kinases and DNA repair gene products are being studied as potential targets or to enhance the efficacy of existing chemotherapeutic agents. The role of growth factors in the progression of solid and hematopoietic tumors is being studied; new receptors and signal transduction pathways are being identified in normal and malignant tissues.

Other areas of research include investigations on interleukin therapy, free radical generation, molecular mechanisms of antioxidant regulation and detoxification, aberrations in the mechanisms of programmed cell death (apoptosis) associated with tumoral growth and alterations in DNA repair and DNA damage response genes associated with tumor growth and chemotherapeutic resistance.

Faculty

altschul@pitt.edu
412.648.9751
feg5@pitt.edu
412-648-2047
euh2@pitt.edu
412-623-3262
yih26@pitt.edu
412-641-3589
yuj5@pitt.edu
412-648-3390
arbelyy@upmc.edu
412-623-3228
can44@pitt.edu
412-641-7725
osullivanr@upmc.edu
412-623-4063
oesterreichs@upmc.edu
412-641-8555
svs2@pitt.edu
412-623-3262
stabilela@upmc.edu
412-623-2015
tasdemirn@upmc.edu
412-641-7736
qjw1@pitt.edu
412-383-7754
gstacy@pitt.edu
412-648-1351
zhanglx@upmc.edu
412-623-1009

Cardiac Mechanisms of Pathogenesis


Faculty

freerad@pitt.edu
412-648-9319
astraub@pitt.edu
412-648-7097

Cardiac Pharmacology


Faculty

freerad@pitt.edu
412-648-9319
pagano@pitt.edu
412-383-6505
astraub@pitt.edu
412-648-7097

Cardiovascular and Renal Pharmacology


Faculty

alb138@pitt.edu
412-648-7347
freerad@pitt.edu
412-648-9319
edj@pitt.edu
412-648-1505
yuj5@pitt.edu
412-648-3390
nkhoo@pitt.edu
412-648-9671
fjs2@pitt.edu
412-648-0193
astraub@pitt.edu
412-648-7097
tofovic@pitt.edu
412-648-3363

Clinical Pharmacology


Faculty

tofovic@pitt.edu
412-648-3363

DNA Repair


Faculty

osullivanr@upmc.edu
412-623-4063
vanhoutenb@upmc.edu
412-623-7762

Drug Discovery

Drug Discovery is an emerging pharmacological science that seeks to identify novel small molecule probes and to understand at a molecular level how compounds affect macromolecular process. Cell-based, in vitro mix-and-read, and whole organism assays suitable for rapid or high throughput analysis are being designed and implemented by members of the Molecular Pharmacology Program. Current molecular targets include Gprotein coupled receptors, vanilloid receptors, cathepsins, apoptosis-inducing proteins, ion channels, steroid receptors, orphan nuclear receptors, kinases, phosphatases, DNA repair enzymes, and DNA polymerases. Chemical libraries and automated screening instrumentation are emphasized, which permit rapid interrogation of optimized assays. Computational approaches and high content cell screening methodologies are employed to facilitate the identification of new chemical probes.

Faculty

mec110@pitt.edu
412-648-2610
maf167@pitt.edu
412-626-2924
freerad@pitt.edu
412-648-9319
yih26@pitt.edu
412-641-3589
yuj5@pitt.edu
412-648-3390
pagano@pitt.edu
412-383-6505
mjp44@pitt.edu
412-383-5900
qianw@upmc.edu
412-623-7804
fjs2@pitt.edu
412-648-0193
svs2@pitt.edu
412-623-3262
jit15@pitt.edu
412-623-3255
vanhoutenb@upmc.edu
412-623-7762
qjw1@pitt.edu
412-383-7754
srw22@pitt.edu
412-648-9671
khxiao@pitt.edu
412-648-1381
zhanglx@upmc.edu
412-623-1009

Endocrine Pharmacology/Physiology


Faculty

jmbeckel@pitt.edu
412-383-5004
wcd2@pitt.edu
412-648-9357
dod1@pitt.edu
412-624-4259

Hormone Pharmacology


Faculty

dod1@pitt.edu
412-624-4259
paf10@pitt.edu
412-383-7783
oesterreichs@upmc.edu
412-641-8555
tasdemirn@upmc.edu
412-641-7736
tofovic@pitt.edu
412-648-3363
khxiao@pitt.edu
412-648-1381

Hormone Signaling and Action


Faculty

dod1@pitt.edu
412-624-4259
paf10@pitt.edu
412-383-7783
leeav@upmc.edu
412-641-7557
tasdemirn@upmc.edu
412-641-7736

Metabolic Syndrome Pharmacology


Faculty

kjf38@pitt.edu
412-383-5901
freerad@pitt.edu
412-648-9319
edj@pitt.edu
412-648-1505
mjp44@pitt.edu
412-383-5900
fjs2@pitt.edu
412-648-0193
tofovic@pitt.edu
412-648-3363

Neuropharmacology

The physiological basis of neuronal toxicity caused by various insults including excitatory amino acids, oxidative stress and cerebral ischemia is being studied using quantitative imaging techniques, confocal microscopy, genetic approaches in model organisms, and molecular approaches in cultured cell lines, cultured primary neurons and in intact animals. These studies aim to develop an understanding of the mechanisms of neuronal injury in acute and chronic disorders. The regulation of the expression of voltage-gated ion channels in cell lines and primary cultures is being studied by molecular and patchclamping techniques. In addition, molecular genetic, electrophysiological and cell biological approaches are being used to explore the relationships between neurotransmitter transporter structure, substrate transport, inhibitor binding and ion permeation. New quantitative imaging approaches are being used to study the basic processes of neuropeptide secretion. Investigators in the Molecular Pharmacology program are also examining the mechanisms of autonomic regulation and synaptic transmission of the urogenital system. These studies include neuroanatomical and neurophysiological research aimed towards the development of agents to modulate neuronal control of the urinary bladder, colon, and sex organs. Targeted disruption of GABA receptors is being used as a tool to investigate the function of these receptors and their specific components in transgenic mice. The mechanism of action of anesthetics is being studied in genetic model organisms and using techniques of magnetic resonance spectroscopy.

Faculty

jmbeckel@pitt.edu
412-383-5004
wcd2@pitt.edu
412-648-9357
dod1@pitt.edu
412-624-4259
kjf38@pitt.edu
412-383-5901
edj@pitt.edu
412-648-1505
tcj11@pitt.edu
412-648-8136
elevitan@pitt.edu
412-648-9486
mjp44@pitt.edu
412-383-5900

Pharmacology of Cell and Organ Systems

Investigators in the Molecular Pharmacology program are also examining the mechanisms of autonomic synaptic transmission and the autonomic regulation of the urogenital and renal systems. These studies include: 1) neuroanatomical and neurophysiological research aimed towards the development of agents to modulate neuronal control of the urinary bladder, colon, and sex organs; 2) biochemical/molecular analysis of the role of PP-fold peptides released from autonomic synaptic junctions in the regulation of renovascular tone and arterial blood pressure in genetic hypertension; and 3) the interaction between the sympathetic nervous system and estradiol on renal function.

Faculty

jmbeckel@pitt.edu
412-383-5004
alb138@pitt.edu
412-648-7347
mec110@pitt.edu
412-648-2610
wcd2@pitt.edu
412-648-9357
dod1@pitt.edu
412-624-4259
maf167@pitt.edu
412-626-2924
paf10@pitt.edu
412-383-7783
edj@pitt.edu
412-648-1505
doctorno@pitt.edu
412-383-8012
leeav@upmc.edu
412-641-7557
tbm7@pitt.edu
412-383-8838
can44@pitt.edu
412-641-7725
oesterreichs@upmc.edu
412-641-8555
pagano@pitt.edu
412-383-6505
mjp44@pitt.edu
412-383-5900
ggr@pitt.edu
412-648-9408
fjs2@pitt.edu
412-648-0193
sss43@pitt.edu
412-383-5854
stabilela@upmc.edu
412-623-2015
astraub@pitt.edu
412-648-7097
vanhoutenb@upmc.edu
412-623-7762
jpv@pitt.edu
412-648-2055
dav28@pitt.edu
412-648-8160
dav18@pitt.edu
412-624-1006
qjw1@pitt.edu
412-383-7754

Protein Kinases & Phosphatases


Faculty

yuj5@pitt.edu
412-648-3390
qjw1@pitt.edu
412-383-7754

Pulmonary Pharmacology


Faculty

tofovic@pitt.edu
412-648-3363

Purine Pharmacology


Faculty

jmbeckel@pitt.edu
412-383-5004
edj@pitt.edu
412-648-1505

Receptor Pharmacology


Faculty

jmbeckel@pitt.edu
412-383-5004
alb138@pitt.edu
412-648-7347
dod1@pitt.edu
412-624-4259
paf10@pitt.edu
412-383-7783
yih26@pitt.edu
412-641-3589
tcj11@pitt.edu
412-648-8136
tbm7@pitt.edu
412-383-8838
ggr@pitt.edu
412-648-9408
sas279@pitt.edu
412-648-2610
fjs2@pitt.edu
412-648-0193
jpv@pitt.edu
412-648-2055
khxiao@pitt.edu
412-648-1381
chengzh@pitt.edu
412-383-8044

Redox Pharmacology


Faculty

mec110@pitt.edu
412-648-2610
maf167@pitt.edu
412-626-2924
kjf38@pitt.edu
412-383-5901
freerad@pitt.edu
412-648-9319
feg5@pitt.edu
412-648-2047
euh2@pitt.edu
412-623-3262
nkhoo@pitt.edu
412-648-9671
doctorno@pitt.edu
412-383-8012
can44@pitt.edu
412-641-7725
pagano@pitt.edu
412-383-6505
mjp44@pitt.edu
412-383-5900
sas279@pitt.edu
412-648-2610
fjs2@pitt.edu
412-648-0193
sss43@pitt.edu
412-383-5854
astraub@pitt.edu
412-648-7097
vanhoutenb@upmc.edu
412-623-7762
dav28@pitt.edu
412-648-8160
gstacy@pitt.edu
412-648-1351

Signal Transduction

The department is rich in research devoted to the analysis of signal transduction pathways and their role in normal physiological processes and disease. These include studies into the basic mechanisms of signaling by oxidizing and free radical inflammatory mediators, nitric oxide, steroids, parathyroid hormone, neurotransmitters, hypothalamic hormones, and rhodopsin. Various cell biological, forward and reverse genetic, molecular biological and biophysical approaches are used to dissect the molecular mechanisms utilized by intracellular mediators of signal transduction including cell surface receptors, nuclear receptors, caveolin, protein kinases, protein phosphatases and lipid kinases.

Faculty

altschul@pitt.edu
412.648.9751
alb138@pitt.edu
412-648-7347
dod1@pitt.edu
412-624-4259
freerad@pitt.edu
412-648-9319
paf10@pitt.edu
412-383-7783
feg5@pitt.edu
412-648-2047
tcj11@pitt.edu
412-648-8136
yuj5@pitt.edu
412-648-3390
doctorno@pitt.edu
412-383-8012
elevitan@pitt.edu
412-648-9486
can44@pitt.edu
412-641-7725
pagano@pitt.edu
412-383-6505
sas279@pitt.edu
412-648-2610
fjs2@pitt.edu
412-648-0193
sss43@pitt.edu
412-383-5854
svs2@pitt.edu
412-623-3262
stabilela@upmc.edu
412-623-2015
astraub@pitt.edu
412-648-7097
jit15@pitt.edu
412-623-3255
jpv@pitt.edu
412-648-2055
dav28@pitt.edu
412-648-8160
qjw1@pitt.edu
412-383-7754
gstacy@pitt.edu
412-648-1351
khxiao@pitt.edu
412-648-1381
chengzh@pitt.edu
412-383-8044
zhanglx@upmc.edu
412-623-1009

Structural Pharmacology


Faculty

arjun@pitt.edu
412-688-6000
dms31@pitt.edu
412-648-8693
paf10@pitt.edu
412-383-7783
fureyw@pitt.edu
412-683-9718
sss43@pitt.edu
412-383-5854
jpv@pitt.edu
412-648-2055
qjw1@pitt.edu
412-383-7754
khxiao@pitt.edu
412-648-1381
chengzh@pitt.edu
412-383-8044

Systems Biology of Cancer


Faculty

feg5@pitt.edu
412-648-2047
leeav@upmc.edu
412-641-7557

Systems Pharmacology


Faculty

jmbeckel@pitt.edu
412-383-5004
jpv@pitt.edu
412-648-2055
khxiao@pitt.edu
412-648-1381