Vilardaga Lab

The Vilardaga laboratory carries an interdisciplinary research program aimed at elucidating molecular mechanisms of signal transduction mediated by G-protein coupled receptors in renal, skeletal and other cell systems.

Lisa Clark
Predoctoral Fellow


Jean-Pierre Vilardaga, PhD
Professor


Alex White
Trainee

Jean-Pierre Vilardaga, PhD

Chelocha RW, SH Gellman, JP Vilardaga and TJ Gardella. Signal transduction at type -1  parathyroid hormone receptor: Mechanistic studies provide insight into GPCR signaling and highlight therapeutic opportunities. Nature Review Endocrinology 11: 712-724, 2015. 
Gardella TJ and JP Vilardaga.  The parathyroid hormone receptors: Family B GPCRs.  Pharmacol Reviews 67: 310-337, 2015.
Vilardaga JP, FG Jean-Alphonse and TJ Gardella. Endosomal generation of cAMP in GPCR signaling. Nature Chemical Biology 10: 700-706, 2014.
Gidon A, MM Al-Bataineh, FG Jean-Alphonse, H Stevenson, T Watanabe, C Louet, A Khatri, G Calero, NM Pastor-Soler, TJ Gardella and JP Vilardaga. Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase. Nature Chem Biol 10: 707-711, 2014.
Feinstein TN, N Yui, MJ Webber, VL Wehbi, HP Stevenson, J Darwin King, Jr., KR Hallows, D Brown, R Bouley and JP Vilardaga.  Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin. J. Biol. Chem 288:27849-27860, 2013.
Wehbi VL, H Stevenson, TN Feinstein, G Calero, G Romero and JP Vilardaga.  Non-canonical GPCR signaling arising from a PTH receptor-arrestin-Gßy complex.  Proc Natl Acad Sci USA 110:1530-1535, 2013.
Vilardaga JP, TJ Gardella, VL Wehbi and TN Feinstein.  Non-canonical signaling of the PTH receptor.  Trends Pharmacol Sci 33:423-431, 2012.
Hanyu R, VL Wehbi, T Hayata, S Moriya, TN Feinstein, Y Yoichi Ezura, M Nagao, Y Saita, H Hemmi, T Notomi, T Nakamoto, E Schipani, S Takeda, K Kaneko, H Kurosawa, G Karsenty, KM Kronenberg, JP Vilardaga and M Noda.  Anabolic action of PTH regulated by the ß2-adrenergic receptor.  Proc Natl Acad Sci USA 109:7433-7438, 2012.
Feinstein TN, VL Wehbi, JA Ardura, DA Wheeler, S Ferrandon, TJ Gardella and JP Vilardaga.  Retromer terminates the generation of cAMP by internalized PTH-receptors.  Nature Chemical Biology 7:278-284,2011.
Ferrandon S, TN Feinstein, C Castro, B Wang R Bouley, JT Potts, TJ Gardella and JP Vilardaga.  Sustained cyclic AMP production by parathyroid hormone receptor endocytosis.  Nature Chemical Biology 5:734-742, 2009.
Okazaki M, S Ferrandon, JP Vilardaga, ML Bouxsein, JT Potts and TJ Gardella. Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation. Proc. Natl. Acad. Sci. USA 105:16525-16530, 2008.
Vilardaga JP, OV Nikolaev, K Lorenz, S Ferrandon, Z Zhuang and MR Lohse. Conformational cross-talk between a2A-adrenergic and m-opioid receptors control cell signaling. Nature Chemical Biology 4:126-131, 2008.
Rochais F, JP Vilardaga, VO Nikolaev, M Bünemann, MJ Lohse and S Engelhardt. Real-time optical recording of b1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. J. Clin. Invest. 117:229-235, 2007.
Vilardaga JP, M  Bünemann, C Krasel, M Castro and MJ Lohse.  Measurement of the millisecond activation switch of G protein-coupled receptors in living cells.  Nature Biotechnology 21:807-812, 2003.
 

Alex White

Dube, S.; Dube, H.; Green, N.B.; Larsen, E.M.; White, A.; et al. In vivo delivery and activation of masked fluorogenic hydrolase substrates by endogenous hydrolases in C. elegans. ChemBioChem. 2017 Sep 19; 18(18): 1807-1813. doi: 10.1002/cbic.201700278. Epub 2017 Aug 7.PMCID:PMC5605452