Drug Discovery
Drug Discovery is an emerging pharmacological science that seeks to identify novel small molecule probes and to understand at a molecular level how compounds affect macromolecular process. Cell-based, in vitro mix-and-read, and whole organism assays suitable for rapid or high throughput analysis are being designed and implemented by members of the Molecular Pharmacology Program. Current molecular targets include Gprotein coupled receptors, vanilloid receptors, cathepsins, apoptosis-inducing proteins, ion channels, steroid receptors, orphan nuclear receptors, kinases, phosphatases, DNA repair enzymes, and DNA polymerases. Chemical libraries and automated screening instrumentation are emphasized, which permit rapid interrogation of optimized assays. Computational approaches and high content cell screening methodologies are employed to facilitate the identification of new chemical probes.

Faculty

mec110@pitt.edu
412-648-2610
maf167@pitt.edu
412-626-2924
freerad@pitt.edu
412-648-9319
yih26@pitt.edu
412-641-3589
yuj5@pitt.edu
412-648-3390
pagano@pitt.edu
412-383-6505
mjp44@pitt.edu
412-383-5900
qianw@upmc.edu
412-623-7804
fjs2@pitt.edu
412-648-0193
svs2@pitt.edu
412-623-3262
jit15@pitt.edu
412-623-3255
vanhoutenb@upmc.edu
412-623-7762
qjw1@pitt.edu
412-383-7754
srw22@pitt.edu
412-648-9671
khxiao@pitt.edu
412-648-1381
zhanglx@upmc.edu
412-623-1009