BS (Biology), University of Portsmouth, England, 1993. MS (Applied Toxicology), University of Portsmouth, England, 1994. PhD (Biochemical Toxicology), Imperial College, University of London, England, 1998. Postdoctoral Scientist, CDC/NIOSH, Morgantown, WV, 1998-2000.
Dr. Flint’s primary research project involves the direct interplay between stress hormones (cortisol, NE, and E), cancer and chemotherapy. This is accomplished through a mechanistic study of administration of stress hormones to cancerous cells, and observing these effects both in vitro and in rodent models. Currently, the focus of Dr Flint’s work is translational breast and ovarian cancer research. Specifically, her research examines hormonal influences on cell cycle regulation and cancer. There are two ongoing research projects which will endeavor to begin to fill a large gap in the literature and are readily translated to the clinic; 1) determine the mechanisms through which catecholamines and glucocorticoids affect DNA damage and repair mechanisms in breast cancer cells and to understand how these hormones affect the efficacy of chemotherapy agents with a focus on high risk BRCA mutation carriers (figure 1) and 2) examine the mechanisms of catecholamines and glucocorticoids on the adaptive immune system, and tumorigenesis using a genetic mouse model and a human cohort in ovarian cancer.
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